The wagon train comes across a devastated wagon party where they find Renaldo, a wounded member of the attacking comancheros who was left to die by his comrades. Caroline Casteel, captured many years ago by Indians, is traded back to a man who brings her to join the wagon train. Madam Sagittarius has a reputation as a con woman and is distrusted by the passengers, except for one, who begins a special relationship with her. Wealthy merchant Martin Gatsby, a man with little compassion for the less able, wants the wagon train to keep rolling and demands that Hale leave an inexperienced rider behind. John Augustus wins a game of cards with a Chinese merchant. His prize turns out to be a beautiful Chinese girl, which the rest of the train takes issue with. In the midst of a dry spell and desperately in need of water, the wagon train stops at the only source of water for miles. But the owner demands an outrageous price. Hawks, wounded and taken prisoner by the Indians, falls in love with one of his captors, Lisa Raincloud. Hale finds a gravely wounded Army officer, The officer is delirious but before he dies he says things which, if true, could seriously tarnish the image of a national hero. Simon Levy and Patrick McGowan both consider themselves unbeatable at checkers, and when each loses to the other over several games their pride is hurt. A woman on the wagon train is kidnapped by Indians, who say they will only return her when the chief's seriously ill son is taken by the wagon train to a doctor and cured. Kurt Davos is badly injured while trying to save Florence Hastings, who is trapped in a runaway wagon. Patrick O'Shaughnessy has come to visit his daughter Eve, believing her to be a respectable married woman. A Bible-quoting marshal joins the wagon train with his prisoner, a young bank robber whom he claims to be trying to reform. A crusader against the consumption of alcohol joins the wagon train, and begins to fall in love with a winemaker. The wagon train finds Sam Darland and a number of orphan boys in an old ghost town. A sea captain traveling west is haunted by nightmares from his past. When his wagon falls down a cliff, Davey Baxter's mother is killed, and his arm is crushed. The doctor is unavailable, so Chris Hale is the one forced to make the decision to amputate Davey'... On his way to Fort David, wagon scout Duke Shannon rescues Sgt. Johnny Masters, a man caught between two worlds. Hawks rides to the Kaylor ranch to buy horses for the wagon train. He finds that the owner John Kaylor has just died. Bitter and alcoholic Stevenson Drake develops a dislike for John Hollister, a fellow Southerner, when he learns he didn't fight for the Confederacy. Duke and Charlie come across a sheriff and his female prisoner, Lily Legend, a childhood sweetheart of Duke's who the sheriff is escorting to be hanged for murder. When children's dolls are found mutilated in her possession, passengers believe that Sara Proctor is either deranged or practicing witchcraft. Duke Shannon stops over in the town of High Times, and almost right away gets into a fight with, and accidentally kills, one of the gunmen who are essentially holding the town hostage. Hale deals with a mysterious bout of typhoid fever ravaging a family. The four Hooper brothers are orphaned when their parents are killed in a wagon accident. The Perez family is run out of their town because people believe their daughter Juana is a witch. While scouting in Wyoming territory, Duke is forced by outlaw Tom Tuesday to act as his guide to an important rendezvous in Ruby City, Idaho. Samuel MacIntosh picks farmer Hamish Browne to marry his daughter Heather, before the two have even met, and gets the young man to sign a contract. Duke comes upon three women under attack by hostile Indians. They are saved by a man named Blane Wessels who appears on the scene. Tom O'Neal and Ellen Howard want to get married, but their parents object, so Tom takes money from his father's savings and runs away with Ellen. Duke and Charlie visit an Army fort to see Duke's friend Clarence Mullins, a minister who was also a lieutenant at the fort. Hale is entrusted to deliver a box containing $8,000 to a bank. Young David Garner is determined to steal the box, and he stows along on the wagon train. Bill Hawks travels to a desert town to visit an old friend, an Indian who has a ranch there. Invalid cattle rancher Henry Ludlow is so determined that his daughter Judy not marry young Basque sheepherder Antone Rose that he sells his land and joins the wagon train to head west. Duke Shannon goes to visit his ranch, Shannon's Glen, which he gave his friend Jim Whitlow a half interest in. Bill meets young Barnaby West, who claims he is traveling west on foot to Sacramento to see his father, a famous frontiersman.